Motif ID: FOX{I1,J2}.p2

Z-value: 1.766


Transcription factors associated with FOX{I1,J2}.p2:

Gene SymbolEntrez IDGene Name
FOXI1 2299 forkhead box I1
FOXJ2 55810 forkhead box J2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXJ2chr12_+_80765080.283.0e-01Click!
FOXI1chr5_+_1694654780.097.5e-01Click!


Activity profile for motif FOX{I1,J2}.p2.

activity profile for motif FOX{I1,J2}.p2


Sorted Z-values histogram for motif FOX{I1,J2}.p2

Sorted Z-values for motif FOX{I1,J2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{I1,J2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_19818209 9.119 NM_018993
RIN2
Ras and Rab interactor 2
chr5_+_159368690 6.583 TTC1
tetratricopeptide repeat domain 1
chr5_+_159368721 5.674 TTC1
tetratricopeptide repeat domain 1
chr4_+_167013859 5.616 NM_012464
TLL1
tolloid-like 1
chr5_+_159368733 5.220 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr5_-_59100194 4.367 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr13_-_32757835 3.720 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr7_+_151284396 3.584 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr4_+_86968069 3.246 ARHGAP24
Rho GTPase activating protein 24
chr9_+_74956601 3.219 ANXA1
annexin A1
chr19_+_57564981 3.133 NM_001145434
ZNF880
zinc finger protein 880
chr9_+_77695334 2.943 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr3_-_170970296 2.880 NM_032487
ARPM1
actin related protein M1
chr9_+_74956494 2.827 NM_000700
ANXA1
annexin A1
chr6_+_150304813 2.823 NM_025217
ULBP2
UL16 binding protein 2
chr3_+_11242666 2.796 NM_001098211
HRH1
histamine receptor H1
chr22_+_44828338 2.768


chr7_-_27186400 2.744 NM_153715
HOXA10
homeobox A10
chr11_+_113672378 2.711 NNMT
nicotinamide N-methyltransferase
chr5_-_54317102 2.708 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr7_-_87687276 2.693 SRI
sorcin
chr20_+_19863716 2.690 RIN2
Ras and Rab interactor 2
chr9_+_130719034 2.654 LRRC8A
leucine rich repeat containing 8 family, member A
chr11_+_113672407 2.567 NNMT
nicotinamide N-methyltransferase
chr22_-_41366550 2.561 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr12_+_27066768 2.556 MED21
mediator complex subunit 21
chr10_+_71231693 2.521 COL13A1
collagen, type XIII, alpha 1
chr8_-_108579270 2.447 NM_001146
ANGPT1
angiopoietin 1
chr10_+_71231649 2.446 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr2_+_201182187 2.399 AOX1
aldehyde oxidase 1
chr4_-_186693574 2.340 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr2_-_189752575 2.293 NM_000393
COL5A2
collagen, type V, alpha 2
chr11_+_113436438 2.273 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr1_-_177378801 2.269 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr12_+_27066749 2.223 NM_004264
MED21
mediator complex subunit 21
chr6_+_121798443 2.149 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_242691295 2.148 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr19_-_56946911 2.108 NM_001193306
NM_002029
FPR1

formyl peptide receptor 1

chr1_+_157246305 2.099 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr9_+_129900637 2.087 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr7_-_87687302 2.019 NM_003130
SRI
sorcin
chr9_+_129900590 2.001 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr9_+_119506446 1.973 TLR4
toll-like receptor 4
chr2_-_144991386 1.962 ZEB2
zinc finger E-box binding homeobox 2
chr9_+_119506428 1.956 TLR4
toll-like receptor 4
chr5_-_59100091 1.955 PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_153060722 1.917 NM_025107
MYCT1
myc target 1
chr1_-_21373816 1.870 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_+_46423682 1.862 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr9_+_119506274 1.862 NM_138554
TLR4
toll-like receptor 4
chr10_+_86174665 1.858 FAM190B
family with sequence similarity 190, member B
chr9_+_74956614 1.791 ANXA1
annexin A1
chr5_+_98132898 1.766 NM_001012761
RGMB
RGM domain family, member B
chr7_-_158304062 1.761 ESYT2
extended synaptotagmin-like protein 2
chr2_-_40593074 1.735 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr6_+_134800533 1.717 LOC154092
hypothetical LOC154092
chr6_+_116939500 1.677 NM_153711
FAM26E
family with sequence similarity 26, member E
chr3_-_115825742 1.673 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_53787187 1.625 NM_006308
HSPB3
heat shock 27kDa protein 3
chr3_-_170347019 1.625 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr2_+_12775814 1.619


chr7_-_13997574 1.608 NM_001163148
ETV1
ets variant 1
chr5_+_54491702 1.587 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr3_-_130761967 1.581 PLXND1
plexin D1
chr3_-_170346760 1.579 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr21_+_29439768 1.566 C21orf7
chromosome 21 open reading frame 7
chr1_+_218768170 1.561 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_+_218768146 1.553 MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_-_77457664 1.547 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr15_+_65205107 1.541 NM_001145102
SMAD3
SMAD family member 3
chr8_+_67201684 1.522 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr7_+_111908143 1.517 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr12_-_9913199 1.515 CLEC2B
C-type lectin domain family 2, member B
chr3_-_191321367 1.492 LEPREL1
leprecan-like 1
chr6_-_56615544 1.485 NM_001723
NM_015548
DST

dystonin

chr17_+_30594192 1.483 NM_144975
SLFN5
schlafen family member 5
chr8_-_13416554 1.483 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr14_+_50096603 1.479 ATL1
atlastin GTPase 1
chr9_-_129381086 1.472 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr12_-_50871953 1.457 NM_001081492
NM_182507
KRT80

keratin 80

chr5_+_147775652 1.440 FBXO38
F-box protein 38
chr1_+_84382529 1.427 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_215998181 1.427 FN1
fibronectin 1
chr9_-_109291575 1.421 KLF4
Kruppel-like factor 4 (gut)
chr9_-_4289915 1.419 GLIS3
GLIS family zinc finger 3
chr9_-_4290028 1.411 NM_001042413
GLIS3
GLIS family zinc finger 3
chr1_+_156229686 1.408 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr1_-_171441234 1.397 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr19_-_53305825 1.382 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr2_+_36777406 1.380 VIT
vitrin
chr12_-_29827952 1.356 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr12_+_29193399 1.350 FAR2
fatty acyl CoA reductase 2
chr7_-_13995811 1.341 ETV1
ets variant 1
chr9_-_88751923 1.338 NM_002048
GAS1
growth arrest-specific 1
chr6_+_49626071 1.325 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr4_-_70861301 1.320 NM_001891
CSN2
casein beta
chr18_-_21184824 1.315


chr1_+_148747110 1.312 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr9_+_112470871 1.295 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr1_+_181421796 1.283 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr9_-_16717887 1.279 BNC2
basonuclin 2
chr6_+_151688327 1.275 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr9_+_5500544 1.274 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr3_-_12561962 1.273 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr5_+_96237923 1.260 ERAP2
endoplasmic reticulum aminopeptidase 2
chr1_-_151866147 1.240 NM_001024213
S100A13
S100 calcium binding protein A13
chr20_-_14266200 1.235 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr12_-_14929991 1.223 NM_000900
NM_001190839
MGP

matrix Gla protein

chr6_-_48186868 1.212 C6orf138
chromosome 6 open reading frame 138
chr1_+_84540921 1.211 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr9_+_674193 1.197


chr22_-_43987978 1.189 KIAA0930
KIAA0930
chr10_+_53744043 1.186 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr19_-_51319769 1.185 NM_207393
IGFL3
IGF-like family member 3
chr9_-_116920232 1.183 NM_002160
TNC
tenascin C
chr11_+_57547928 1.150 NM_001005212
OR9Q1
olfactory receptor, family 9, subfamily Q, member 1
chr3_-_71196696 1.143 FOXP1
forkhead box P1
chr7_+_28692122 1.141 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr9_+_12764988 1.134 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr10_-_14090459 1.118 FRMD4A
FERM domain containing 4A
chr15_-_53587723 1.108 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr21_-_42219849 1.108 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr9_+_102380156 1.091 NM_001018116
MURC
muscle-related coiled-coil protein
chr19_-_19793512 1.088 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chr2_-_133145539 1.085 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr12_+_118100977 1.081 NM_014365
HSPB8
heat shock 22kDa protein 8
chr3_-_21767819 1.079 NM_024697
ZNF385D
zinc finger protein 385D
chr1_-_151866367 1.076 NM_001024212
S100A13
S100 calcium binding protein A13
chr10_+_71232281 1.063 COL13A1
collagen, type XIII, alpha 1
chr12_+_55201854 1.062 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr9_-_25668855 1.060 NM_001004125
TUSC1
tumor suppressor candidate 1
chr11_-_101292462 1.052 NM_178127
ANGPTL5
angiopoietin-like 5
chr17_+_26322168 1.050 RNF135
ring finger protein 135
chr12_+_47584159 1.043 NM_033124
CCDC65
coiled-coil domain containing 65
chr1_+_99884018 1.042 NM_017734
PALMD
palmdelphin
chr17_-_31219943 1.036 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr5_+_159546951 1.032 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr12_-_9913724 1.025 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr1_+_84382562 1.020 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_112682401 1.017 LAMA4
laminin, alpha 4
chr8_-_72436519 1.016 EYA1
eyes absent homolog 1 (Drosophila)
chr6_-_112682459 1.016 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr11_+_111551417 1.012 NM_031938
BCO2
beta-carotene oxygenase 2
chr14_+_78815406 1.008 NM_001105250
NM_138970
NRXN3

neurexin 3

chr6_+_114285209 1.005 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr5_+_149960820 1.003 NM_001166208
SYNPO
synaptopodin
chr13_+_22653059 1.001 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chrX_-_23955223 0.999 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr17_+_26322081 0.996 NM_001184992
NM_032322
NM_197939
RNF135


ring finger protein 135


chr16_+_29971955 0.992 ALDOA
aldolase A, fructose-bisphosphate
chr13_-_73605914 0.987 NM_007249
KLF12
Kruppel-like factor 12
chrX_+_135106578 0.984 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr2_-_160765008 0.983 ITGB6
integrin, beta 6
chr9_-_116608113 0.979 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr12_-_12740387 0.977 NM_006143
GPR19
G protein-coupled receptor 19
chr7_+_150442652 0.969 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chrX_+_15428820 0.968 NM_203281
BMX
BMX non-receptor tyrosine kinase
chrX_-_19598912 0.959 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr9_-_87904844 0.955 NM_177937
GOLM1
golgi membrane protein 1
chr8_-_23317620 0.955 NM_002318
LOXL2
lysyl oxidase-like 2
chr1_+_176329578 0.954 RASAL2
RAS protein activator like 2
chr4_+_128773529 0.952 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr10_-_118022707 0.950 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr7_+_75892187 0.949 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr11_+_7997366 0.949 TUB
tubby homolog (mouse)
chr14_+_50096492 0.948 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr8_-_23317577 0.945 LOXL2
lysyl oxidase-like 2
chr9_-_109291866 0.937 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr2_-_144991556 0.937 ZEB2
zinc finger E-box binding homeobox 2
chr2_-_188021117 0.934 NM_005795
CALCRL
calcitonin receptor-like
chr12_+_10256682 0.933 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr6_-_112682573 0.930 LAMA4
laminin, alpha 4
chr8_-_93176618 0.929 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr5_+_55182963 0.924 NM_139017
IL31RA
interleukin 31 receptor A
chr7_+_120415958 0.922 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr6_-_117853710 0.921 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr15_+_37330176 0.914 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr6_-_128883125 0.909 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr1_+_162795538 0.906 PBX1
pre-B-cell leukemia homeobox 1
chr3_+_62280435 0.893 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr2_-_151052391 0.890 NM_005168
RND3
Rho family GTPase 3
chr10_+_94584449 0.890 NM_001013848
EXOC6
exocyst complex component 6
chr22_+_43527101 0.889 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr3_+_138159396 0.889 NM_144717
IL20RB
interleukin 20 receptor beta
chr11_+_101488380 0.888 NM_001195045
YAP1
Yes-associated protein 1
chr21_-_41140457 0.884 DSCAM
Down syndrome cell adhesion molecule
chr3_-_55489973 0.883 WNT5A
wingless-type MMTV integration site family, member 5A
chr3_-_113495763 0.874 NM_183061
SLC9A10
solute carrier family 9, member 10
chr2_-_134042500 0.872 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chrX_-_50403412 0.869 SHROOM4
shroom family member 4
chr3_-_191321601 0.865 NM_018192
LEPREL1
leprecan-like 1
chr13_-_77391525 0.863


chr2_+_102320148 0.860 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr13_+_31318828 0.860 EEF1DP3
eukaryotic translation elongation factor 1 delta pseudogene 3
chr8_-_13178399 0.858 DLC1
deleted in liver cancer 1
chr1_-_168310232 0.852 NM_014970
KIFAP3
kinesin-associated protein 3
chr14_+_57964462 0.848 NM_014749
KIAA0586
KIAA0586
chr3_+_137224266 0.845 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr16_+_29971971 0.842 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chrX_+_100361588 0.842 NM_001171184
NM_001939
DRP2

dystrophin related protein 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.64 6.86e-04 GO:2000026 regulation of multicellular organismal development
1.19 1.41e-03 GO:0032501 multicellular organismal process
1.54 2.54e-03 GO:0050793 regulation of developmental process
1.32 4.83e-03 GO:0048523 negative regulation of cellular process
1.95 5.16e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.79 9.89e-03 GO:0009968 negative regulation of signal transduction
1.30 1.07e-02 GO:0048519 negative regulation of biological process
1.59 1.48e-02 GO:0045595 regulation of cell differentiation
2.41 2.74e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.71 3.12e-02 GO:0023057 negative regulation of signaling
2.39 3.23e-02 GO:0022604 regulation of cell morphogenesis
1.71 3.39e-02 GO:0010648 negative regulation of cell communication
1.22 3.73e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 4.06e-04 GO:0071944 cell periphery
1.22 4.39e-04 GO:0005886 plasma membrane
1.82 5.96e-03 GO:0005578 proteinaceous extracellular matrix
1.42 1.03e-02 GO:0044421 extracellular region part
2.86 1.40e-02 GO:0030427 site of polarized growth
1.27 2.27e-02 GO:0005576 extracellular region
1.43 2.99e-02 GO:0042995 cell projection
2.78 3.31e-02 GO:0030426 growth cone
1.63 4.56e-02 GO:0044463 cell projection part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 2.81e-02 GO:0005515 protein binding